Let's take a detailed look at the data to compare the profitability of betting on the NFL, MLB, NBA, college football, and college basketball. Best Sports to Bet on the Moneyline College Football (159.23% OPT. ROI SCORE) NFL (78.7% OPT. College Basketball (29.22% OPT. NBA (13.92% OPT. NHL (10.07% OPT. MLB (7.34% OPT.